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Acute phase reactants in patients with coronary slow flow phenomenon [Anatol J Cardiol]
Anatol J Cardiol. 2010; 10(5): 416-420 | DOI: 10.5152/akd.2010.139  

Acute phase reactants in patients with coronary slow flow phenomenon

Nihat Madak1, Yunus Nazlı2, Haluk Mergen3, Süleyman Aysel1, Muhammet Kandaz1, Demet Çekdemir4, Talat Tavlı5
1Department of Cardiology, Surgery Faculty of Medicine, University of Celal Bayar, Manisa
2Department of Cardiovascular Surgery Faculty of Medicine, Celal Bayar University, Manisa
3Department of Medicosocial Faculty of Medicine, Celal Bayar University, Manisa
4Department of Internal Medicine, Faculty of Medicine, University of Celal Bayar, Manisa
5Department of Cardiology, Faculty of Medicine, Celal Bayar University, Manisa

Objective: In this study, we sought to investigate the serum levels of high sensitivity C-reactive protein (Hs-CRP), N-terminal pro-brain natriuretic peptide (NT proBNP), erythrocyte sedimentation rate, leukocyte, thyroid hormone and fibrinogen levels in patients with coronary slow flow phenomenon (CSFP). Methods: A total of 82 patients with angiographically proven normal coronary arteries and slow coronary flow in all three coronary vessels (45 males and 37 females, mean age 59±11 years) and 34 patients with normal coronary arteries and normal coronary flow (19 males and 15 females, mean age 56±10 years) with similar risk profiles were included in this cross-sectional observational study. Coronary flow rates of all patients and control subjects were documented by Thrombolysis In Myocardial Infarction (TIMI) frame count, serum level of Hs-CRP, NT proBNP, sedimentation, leukocyte, free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH) and fibrinogen levels were measured. Statistical analysis was performed using t test for independent samples, Chi-square test and Pearson correlation analysis. Results: Hs-CRP (0.88±0.86 vs 0.36±0.35 mg/L, p<0.001) and NT proBNP (117.83±163.2 vs 47.33±30.6 ng/ml, p<0.01) were found to be significantly higher in patients with coronary slow flow compared with normal control group. There were no significant differences regarding thyroid hormones, fibrinogen, sedimentation rate and leukocyte count between two groups. The mean TIMI frame counts were positively correlated (r=0.454, p=0.001 and r=0.554, p=0.001, respectively) with plasma Hs-CRP levels and NT-proBNP levels. Conclusion: Hs-CRP and NT proBNP are significantly higher in patients with coronary slow flow compared with normal control group. Their increased levels are positively correlated with TIMI frame count.

Keywords: Coronary artery disease, coronary angiography, coronary slow flow, C-reactive protein, N-terminal pro-brain natriuretic peptide


Nihat Madak, Yunus Nazlı, Haluk Mergen, Süleyman Aysel, Muhammet Kandaz, Demet Çekdemir, Talat Tavlı. Acute phase reactants in patients with coronary slow flow phenomenon. Anatol J Cardiol. 2010; 10(5): 416-420


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