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Design and rationale for the ASSOS study: Appropriateness of aspirin use in medical outpatients a multicenter and observational study [Anatol J Cardiol]
Anatol J Cardiol. 2018; 20(6): 354-362 | DOI: 10.14744/AnatolJCardiol.2018.47587  

Design and rationale for the ASSOS study: Appropriateness of aspirin use in medical outpatients a multicenter and observational study

Oğuzhan Çelik1, Cem Çil1, Bülent Özlek1, Eda Özlek1, Volkan Doğan1, Özcan Başaran1, Erkan Demirci2, Lütfü Bekar3, Macit Kalçık3, Osman Karaarslan3, Mücahit Yetim3, Tolga Doğan3, Vahit Demir4, Sedat Kalkan5, Buğra Özkan6, Şıho Hidayet7, Gökay Taylan8, Zafer Küçüksu9, Yunus Çelik10, Süleyman Çağan Efe11, Onur Aslan12, Murat Biteker1
1Department of Cardiology, Faculty of Medicine, Muğla Sıtkı Koçman University; Muğla-Turkey
2Department of Cardiology, Kayseri Training and Research Hospital; Kayseri-Turkey
3Department of Cardiology, Hitit University Erol Olçok Training and Research Hospital; Çorum-Turkey
4Department of Cardiology, Faculty of Medicine, Yozgat Bozok University; Yozgat-Turkey
5Department of Cardiology, Pendik State Hospital; İstanbul-Turkey
6Department of Cardiology, Faculty of Medicine, Mersin University; Mersin-Turkey
7Department of Cardiology, Faculty of Medicine, Malatya İnönü University; Malatya-Turkey
8Department of Cardiology, Faculty of Medicine, Trakya University; Edirne-Turkey
9Department of Cardiology, Faculty of Medicine, Erzincan University; Erzincan-Turkey
10Department of Cardiology, Kırıkkale Yüksek İhtisas Hospital; Kırıkkale-Turkey
11Department of Cardiology, Samatya Training and Research Hospital; İstanbul-Turkey
12Department of Cardiology, Tarsus State Hospital; Mersin-Turkey

Objective: The aim of this study was to describe the current status of aspirin use and the demographic characteristics of patients on aspirin for primary and secondary prevention of cardiovascular diseases.
Methods: The Appropriateness of Aspirin Use in Medical Outpatients: A Multicenter, Observational Study (ASSOS) trial was a multicenter, cross-sectional, and observational study conducted in Turkey. The study was planned to include 5000 patients from 14 cities in Turkey. The data were collected at one visit, and the current clinical practice regarding aspirin use was evaluated (ClinicalTrials.gov number NCT03387384).
Results: The study enrolled all consecutive patients who were admitted to the outpatient cardiology clinics from March 2018 until June 2018. Patients should be at least 18 years old, have signed written informed consent, and on aspirin (80–325 mg) therapy within the last 30 days. Cardiologists from the hospital participates in the study. Patients were divided into 2 categories according to presence or absence of atherosclerotic cardiovascular disease, namely secondary prevention group and primary prevention group, respectively. The appropriate use of aspirin in the primary and secondary prevention groups was assessed according to the European Society of Cardiology guidelines and US Preventive Services Task Force. The patients’ gastrointestinal bleeding risk factors and colorectal cancer risk were evaluated.
Conclusion: The ASSOS registry will be the most comprehensive and largest study in Turkey evaluating the appropriateness of aspirin use. The results of this study help understand the potential misuse of aspirin in a real-world setting.

Keywords: aspirin, primary prevention, outpatients, secondary prevention


Oğuzhan Çelik, Cem Çil, Bülent Özlek, Eda Özlek, Volkan Doğan, Özcan Başaran, Erkan Demirci, Lütfü Bekar, Macit Kalçık, Osman Karaarslan, Mücahit Yetim, Tolga Doğan, Vahit Demir, Sedat Kalkan, Buğra Özkan, Şıho Hidayet, Gökay Taylan, Zafer Küçüksu, Yunus Çelik, Süleyman Çağan Efe, Onur Aslan, Murat Biteker. Design and rationale for the ASSOS study: Appropriateness of aspirin use in medical outpatients a multicenter and observational study. Anatol J Cardiol. 2018; 20(6): 354-362

Corresponding Author: Oğuzhan Çelik, Türkiye


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