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Serum cystatin C and neutrophil gelatinase-associated lipocalin in predicting the severity of coronary artery disease in diabetic patients [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(10): 756-761 | DOI: 10.5152/AnatolJCardiol.2015.6645  

Serum cystatin C and neutrophil gelatinase-associated lipocalin in predicting the severity of coronary artery disease in diabetic patients

Kaan Okyay, Aylin Yıldırır, Mutlu Çiçek, Alp Aydınalp, Haldun Müderrisoğlu
Department of Cardiology, Faculty of Medicine, Başkent University Ankara Education and Research Hospital, Ankara- Turkey

Objective: Cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) are biomarkers of renal functions. We evaluated their roles in predicting the severity of coronary artery disease (CAD).
Methods: Fifty-two consecutive type 2 diabetic patients (32 males, 65.7±8.6 years) who underwent coronary angiography (CAG) for stable CAD were included in this single-center, prospective, cross-sectional study. Patients with an estimated glomerular filtration rate <60 mL/min/1.73 m2 and with a history of by-pass surgery and/or coronary stent implantation were excluded. The vessel score and Gensini score were calculated to assess the presence and severity of CAD. Mann–Whitney U test, Spearman test, and multiple linear regression analysis were used for the main statistical analyses.
Results: Serum cystatin C levels were higher in patients with multivessel disease than in those with single vessel disease [1260 ng/mL (953–1640) vs. 977 ng/mL (599–1114), p=0.017]. According to the median Gensini score, the higher score group also had higher cystatin C levels than the lower score group [1114 ng/mL (948–1567) vs. 929 ng/mL (569–1156), p=0.009]. However, serum NGAL levels were similar between these subgroups. There was a positive correlation between cystatin C and Gensini score (r=0.334, p=0.016). Multiple linear regression analysis revealed serum cystatin C as an independent predictor of the Gensini score (β=0.360, t=2.311, p=0.026). These results may aid in defining cystatin C as a surrogate marker of the extent of CAD in further clinical trials.
Conclusion: Serum Cystatin C, but not NGAL levels, could predict the severity of CAD in diabetic patients. (Anatol J Cardiol 2016; 16: 756-61)

Keywords: coronary artery disease, cystatin C, neutrophil gelatinase-associated lipocalin, diabetes mellitus


Kaan Okyay, Aylin Yıldırır, Mutlu Çiçek, Alp Aydınalp, Haldun Müderrisoğlu. Serum cystatin C and neutrophil gelatinase-associated lipocalin in predicting the severity of coronary artery disease in diabetic patients. Anatol J Cardiol. 2016; 16(10): 756-761

Corresponding Author: Kaan Okyay, Türkiye


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