ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 20 Issue : 4
Current Issue Archive Popular Article Ahead of Print

   
Quick Search





 
Insulin resistance is related with oxidative stress in systemic lupus erythematosus [Anatol J Cardiol]
Anatol J Cardiol. 2009; 9(1): 23-28

Insulin resistance is related with oxidative stress in systemic lupus erythematosus

Süleyman Serdar Koca1, Ilgın Karaca2, Mustafa Ferzeyn Yavuzkır2, Necati Dağlı2, Metin Özgen1, Bilal Üstündağ5, Ahmet Işık6
1Department of Rheumatology, Faculty of Medicine, Fırat University, Elazığ, Turkey
2Department of Cardiology, Medical School, Fırat University, Elazığ, Turkey
3Department of Cardiology, Medical School, Fırat University, Elazığ, Turkey
4Department of Cardiology, Medical School, Fırat University, Elazığ, Turkey
5Department of Biochemistry, Faculty of Medicine, Fırat University, Elazığ, Turkey
6Department of Rheumatology, Medical School, Fırat University, Elazığ, Turkey

Objective: Systemic lupus erythematosus (SLE) patients have increased risk of coronary heart disease (CHD) that cannot be fully explained by the traditional risk factors. Metabolic alterations like oxidative stress and insulin resistance may be additional risk factors to contribute early and accelerated atherosclerosis in SLE. Our aim was to evaluate malondialdehyde (MDA) level, oxidative stress indicator, and homeostasis model assessment of insulin resistance (HOMA-IR), and possible relationship between oxidative stress and insulin resistance, in SLE. Methods: This cross-sectional controlled study included 30 SLE patients (SLE group) and 15 age- and sex-matched healthy controls (HC group). The SLE patients were classified into subgroups based on the disease activity index as active or inactive. Serum MDA, insulin, C-peptide, fasting blood glucose, lipid profile, acute phase reactants, tumor necrosis factor (TNF)-a, interleukin (IL)-6 and HOMA-IR were determined. Statistical analyses were performed using Kruskal-Wallis, Mann-Whitney U and Pearson tests. Results: In the SLE group, TNF-a (7.9 [0.5-57.8] vs. 3.9 [0.3-6.3] pg/ml, p<0.01), IL-6 (9.2 [0.1-33.9] vs. 2.2 [0.1-4.8] pg/ml, p<0.01), MDA (2.3 [0.1-6.7] vs. 0.95 [0.5-2.96] nmol/ml, p<0.01) and C-peptide (1.9 [0.9-3.5] vs. 1.5 [1.1-2.4] ng/ml, p<0.01) levels were higher than in the HC group, while HOMA-IR index (1.7 [0.5-6.5] vs. 1.2 [0.8-2.9], p>0.05) was nonsignificantly higher. In the SLE group, MDA levels were correlated with insulin (r=0.614, p<0.05) and HOMA-IR (r=0.601, p<0.05). Conclusion: In inflammatory diseases, relations between oxidative stress and insulin resistance, each of them triggers or enhances the other one, come to an impasse. In conclusion, this modifiable impasse might be important to prevent the development of atherosclerosis in SLE.

Keywords: Insulin resistance, HOMA-IR, oxidative stress, malondialdehyde, inflammation, systemic lupus erythematosus


Süleyman Serdar Koca, Ilgın Karaca, Mustafa Ferzeyn Yavuzkır, Necati Dağlı, Metin Özgen, Bilal Üstündağ, Ahmet Işık. Insulin resistance is related with oxidative stress in systemic lupus erythematosus. Anatol J Cardiol. 2009; 9(1): 23-28


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share


Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright © 2018 Turkish Society of Cardiology