ISSN 2149-2263 | E-ISSN 2149-2271
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Evaluation of serum platelet-derived growth factor receptor-ß and brain-derived neurotrophic factor levels in microvascular angina [Anatol J Cardiol]
Anatol J Cardiol. 2020; 24(6): 397-404 | DOI: 10.14744/AnatolJCardiol.2020.44388

Evaluation of serum platelet-derived growth factor receptor-ß and brain-derived neurotrophic factor levels in microvascular angina

Gamze Aslan1, Veli Polat2, Evin Bozcali1, Mustafa Hakan Şahin2, Nurcan Çetin3, Dilek Ural1
1Department of Cardiology, Faculty of Medicine, Koç University Hospital; İstanbul-Turkey
2Department of Cardiology, Bakırköy Dr. Sadi Konuk Training and Research Hospital; İstanbul-Turkey
3Düzen Laboratory; İstanbul-Turkey

Objective: Microvascular angina (MVA) is a coronary microcirculation disease. Research on microcirculatory dysfunction has revealed several biomarkers involved in the etiopathogenesis of MVA. Platelet-derived growth factor receptor β (PDGFR-β) and brain-derived neurotrophic factor (BDNF) are 2 biomarkers associated with microcirculation, particularly pericytes function. The aim of this study was to investigate the role of PDGFR-β and BDNF in MVA.
Methods: Ninety-one patients (median age, 56 y; age range, 40–79 y; 36 men) with MVA and 61 control group subjects (median age, 52 y; age range, 38–76 y; 29 men) were included in the study. Serum concentrations of PDGFR-β and BDNF were measured with commercially available enzyme-linked immunosorbent assay kits.
Results: PDGFR-β [2.82 ng/ml; interquartile range (IQR), 0.57–7.79 ng/ml vs. 2.27 ng/ml; IQR, 0.41–7.16 ng/ml; p<0.0005] and BDNF (2.41 ng/ml; IQR, 0.97–7.97 ng/ml vs. 1.92 ng/ml; IQR, 1.07–6.67 ng/ml; p=0.023) concentrations were significantly higher in patients with MVA compared with the controls. PDGFR-β correlated positively with age (r=0.26, p=0.001), low-density lipoprotein (r=0.18; p=0.02), and BDNF (r=0.47; p<0.001), and BDNF showed a significant positive correlation with age (r=0.20; p=0.01). In binary logistic regression analysis, high-sensitivity C-reactive protein, uric acid, and PDGFR-β values were found to be independent predictors of MVA.
Conclusion: MVA is associated with higher PDGFR-β and BDNF levels. This association may indicate an abnormality in microvascular function. Future studies are required to determine the role of these biomarkers in the pathogenesis of MVA.

Keywords: brain-derived neurotrophic factor, microvascular angina, pericytes, platelet-derived growth factor receptor beta

Gamze Aslan, Veli Polat, Evin Bozcali, Mustafa Hakan Şahin, Nurcan Çetin, Dilek Ural. Evaluation of serum platelet-derived growth factor receptor-ß and brain-derived neurotrophic factor levels in microvascular angina. Anatol J Cardiol. 2020; 24(6): 397-404

Corresponding Author: Gamze Aslan, Türkiye
Manuscript Language: English


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