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Hazelnut consumption decreases the susceptibility of LDL to oxidation, plasma oxidized LDL level and increases the ratio of large/small LDL in normolipidemic healthy subjects [Anatol J Cardiol]
Anatol J Cardiol. 2010; 10(1): 28-35

Hazelnut consumption decreases the susceptibility of LDL to oxidation, plasma oxidized LDL level and increases the ratio of large/small LDL in normolipidemic healthy subjects

Fulya Balaban Yücesan1, Asım Örem1, Birgül Vanizor Kural1, Cihan Örem2, İbrahim Turan1
1Department of Medical Biochemistry Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
2Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey

Objective: Nut consumption has beneficial effects on protection for development of atherosclerotic process. Methods: Single intervention study design was used to determine the effects of hazelnut-enriched diet (1 g/kg/day) during 4 weeks period on atherogenic tendency of low-density lipoprotein (LDL) by evaluating susceptibility of LDL to oxidation, α-tocopherol content of LDL, LDL subfractions, plasma oxidized (ox) LDL, lipid and lipoprotein levels in normolipidemic healthy subjects (n=21). Statistical analysis was performed using paired t test, ANOVA for repeated measurements test, Pearson’s and Spearman correlation analyses. Results: Lag time for oxidation (baseline 54.6±12.3 min, 15th day 59.3±13.4 min, 30th day 65.2±17.8 min, p=0.001) and α-tocopherol content of LDL (baseline 4.82±1.2 μg/mg LDL protein, 15th day 4.88±1.4 μg/mg LDL protein, 30th day 5.35±1.7 μg/mg LDL protein, p=0.02) were found to be increased while ox-LDL levels (baseline 57.2±16.2 U/L, 15th day 51.2±13.6 U/L, 30th day 48.2±14.2 U/L, p=0.001) decreased during the study period. Total cholesterol, LDL-cholesterol, apolipoprotein (apo) B and apo B/apo AI ratio were found to be significantly lower while apo AI was higher (p<0.05). In respect to LDL subfraction, ratio of large/small LDL was significantly increased at the end of the study (baseline 3.79±1.35, 15th day 3.41±1.60, 30th day 4.28±2.44, p= 0.046). Conclusion: Hazelnut-enriched diet may play important role in decrease in atherogenic tendency of LDL by lowering the susceptibility of LDL to oxidation and plasma ox-LDL levels, and increasing the ratio of large/small LDL beyond its beneficial effect on lipid and lipoprotein levels.

Keywords: Hazelnut consumption, oxidized LDL, atherogenic tendency of LDL, ?-tocopherol, lipids


Fulya Balaban Yücesan, Asım Örem, Birgül Vanizor Kural, Cihan Örem, İbrahim Turan. Hazelnut consumption decreases the susceptibility of LDL to oxidation, plasma oxidized LDL level and increases the ratio of large/small LDL in normolipidemic healthy subjects. Anatol J Cardiol. 2010; 10(1): 28-35


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