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Relationship of serum salusin beta levels with coronary slow flow [Anatol J Cardiol]
Anatol J Cardiol. 2019; 22(4): 177-184 | DOI: 10.14744/AnatolJCardiol.2019.43247  

Relationship of serum salusin beta levels with coronary slow flow

Aydın Akyüz1, Fatma Aydın2, Şeref Alpsoy1, Demet Ozkaramanli Gur1, Savas Guzel3
1Department of Cardiology, Faculty of Medicine, Namık Kemal University; Tekirdağ-Turkey
2Department of Cardiovascular Physiology, Institute of Health Sciences, Faculty of Medicine, Namık Kemal University; Tekirdağ-Turkey
3Department of Biochemistry, Faculty of Medicine, Namık Kemal University; Tekirdağ-Turkey

Objective: The pathophysiology of coronary slow flow (CSF) has not been clarified. Salusin-β is released predominantly from the atheroma plaques and influences the pathophysiologic processes of atherosclerosis. Therefore, this study aimed to determine serum salusin-β levels in CSF and its correlation with CSF.
Methods: The study included 39 patients with CSF, and the control group (n=42) consisted of consecutive subjects with normal coronary arteriogram. We measured salusin-β and thrombolysis in myocardial infarction frame count (TFC).
Results: Age, body mass index (BMI), systolic blood pressure, diabetes, hyperlipidemia, and smoking rates were similar (p values>0.05) in both groups. High sensitive C-reactive protein (2.80±1.2 vs. 2.21±1.2 mg/dL, p=0.011), salusin-β [1205 (330–2092) vs. 162 (29–676), pg/ml, p<0.001], corrected TFC of left anterior descending coronary artery (29±9 vs. 19.7±3.7, p<0.001), circumflex artery TFC (25±10 vs. 15±3.2, p<0.001), right coronary artery TFC (28±7.1 vs. 13±3.3, p<0.001), and mean TFC (28±4.4 vs. 16±3.7, p<0.001) were significantly higher in the CSF group. In univariate and multivariate regression analysis, only BMI (unstandardized β±SE=0.178±0.08, p=0.036) and salusin-β levels (unstandardized β±SE=0.006±0.01, p<0.001) were determined as predictors of CSF. There was a good correlation between serum salusin-β and mean TFC values (r=0.564; p<0.001).
Conclusion: There is an association between serum salusin-β levels and CSF.

Keywords: atherosclerosis, coronary slow flow, salusin-β,, endothelial dysfunction


Aydın Akyüz, Fatma Aydın, Şeref Alpsoy, Demet Ozkaramanli Gur, Savas Guzel. Relationship of serum salusin beta levels with coronary slow flow. Anatol J Cardiol. 2019; 22(4): 177-184

Corresponding Author: Aydın Akyüz, Türkiye


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