ISSN 2149-2263 | E-ISSN 2149-2271
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AB0 blood types: impact on development of prosthetic mechanical valve thrombosis [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(11): 820-823 | DOI: 10.14744/AnatolJCardiol.2016.6544

AB0 blood types: impact on development of prosthetic mechanical valve thrombosis

Mehmet Ali Astarcıoğlu1, Macit Kalçık2, Mahmut Yesin2, Mustafa Ozan Gürsoy2, Taner Şen1, Süleyman Karakoyun2, Sabahattin Gündüz2, Mehmet Özkan2
1Department of Cardiology, Evliya Çelebi Training and Research Hospital; Kütahya-Turkey
2Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital; İstanbul-Turkey

Objective: The non-O alleles of the ABO genotype have been associated with an increased risk of thrombosis. We aimed to assess the associa- tion between blood group status and prosthetic valve thrombosis.
Methods: The association between AB0 blood group status and prosthetic valve thrombosis was assessed in this retrospective study. Trans- esophageal echocardiography was performed in 149 patients with a diagnosis of prosthetic valve thrombosis and in 192 control subjects. Results: Non-0 blood group type (p<0.001), presence of NYHA class III-IV status (p<0.001), and central nervous system (p<0.001) and non-central nervous system (p<0.001) emboli were significantly more prevalent in prosthetic valve thrombosis patients than in the control subjects. The incidence of ineffective anticoagulation was higher in patients with prosthetic valve thrombosis than in controls (p<0.001), as was the presence of moderate to severe left atrial spontaneous echo contrast (p<0.001). The non-0 blood prosthetic valve thrombosis subgroup had a higher inci- dence of obstructive thrombi and central nervous system thrombotic events than having 0 blood prosthetic valve thrombosis subgroup. Non-0 blood group, ineffective anticoagulation, left atrial spontaneous echo contrast, and a poor NYHA functional capacity were identified to be the predictors of prosthetic valve thrombosis.
Conclusion: Our data demonstrate that patients with non-0 compared with 0 blood groups have higher incidence of prosthetic valve thrombosis and central nervous system embolism and similar rates of non-central nervous system embolism at presentation compared with 0 blood group type. Thus, non-O blood group may be a risk factor that may be prone to the development of prosthetic valve thrombosis in patients with pros- thetic heart valves. (Anatol J Cardiol 2016; 16: 820-3)

Keywords: prosthetic valve thrombosis, ABO blood group status, transesophageal echocardiogra

Mehmet Ali Astarcıoğlu, Macit Kalçık, Mahmut Yesin, Mustafa Ozan Gürsoy, Taner Şen, Süleyman Karakoyun, Sabahattin Gündüz, Mehmet Özkan. AB0 blood types: impact on development of prosthetic mechanical valve thrombosis. Anatol J Cardiol. 2016; 16(11): 820-823

Corresponding Author: Mehmet Ali Astarcıoğlu, Türkiye
Manuscript Language: English


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