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Association between carotid intima-media thickness and presence of coronary artery disease in chronic obstructive pulmonary disease patients [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(8): 601-607 | DOI: 10.5152/AnatolJCardiol.2015.6440  

Association between carotid intima-media thickness and presence of coronary artery disease in chronic obstructive pulmonary disease patients

Cemal Köseoğlu1, Özge Kurmuş2, Ahmet Göktuğ Ertem3, Büşra Çolak3, Emine Bilen3, Göktürk İpek4, Tahir Durmaz3, Telat Keleş3, Engin Bozkurt3
1Department Of Cardiology, Ankara Training And Research Hospital, Ankara- Turkey
2Department Of Cardiology, Tarsus State Hospital, Mersin- Turkey
3Department Of Cardiology, Atatürk Training And Research Hospital, Ankara- Turkey
4Siyami Ersek Thoracic And Cardiovascular Surgery Centre, Training And Research Hospital, İstanbul- Turkey

Objective: Chronic obstructive pulmonary disease (COPD) is a risk factor for cardiovascular disease (CVD). Carotid intima-media thickness (CIMT) is the sign of subclinical atherosclerosis. Therefore, the aim of this study was to evaluate whether CIMT measurement is related with significant coronary artery disease (CAD) in patients with COPD, similar to those without COPD.
Methods: One hundred and eight patients with previously diagnosed COPD and 78 patients without COPD who underwent coronary angiography (CAG) were enrolled in this prospective cross-sectional study. Carotid artery ultrasonography was performed on all patients after coronary angiography by another operator who was blind to the CAG results. The patients were divided into four subgroups as follows: group 1: COPD (−) and CAD (−); group 2: COPD (−) and CAD (+); group 3: COPD (+) and CAD (+); and group 4: COPD (+) and CAD (−). Patients with previous coronary revascularization, carotid artery disease, and lung disease other than COPD were not enrolled in this study. The student’s t-test, chi-square analysis, multiple logistic regression analysis, and receiver operating characteristic (ROC) curve were used for statistical analysis.
Results: CIMT was found to be highest in patients with both significant CAD and COPD (group 3) (p<0.05). Among the 108 COPD patients, the odds ratio associated with the CIMT >1.25 mm to predict CAD was 12.4. The area under the ROC curve for a cut-off value of 1.25 mm for CIMT to predict CAD in COPD patients was calculated as 0.913, with a sensitivity of 89.7% and specificity of 86.7%.
Conclusion: CIMT has a predictive value for the presence of CAD in patients with COPD. Further studies are needed to validate our results. (Anatol J Cardiol 2016; 16: 000-00)

Keywords: chronic obstructive pulmonary disease, coronary artery disease, carotid intima-media thickness


Cemal Köseoğlu, Özge Kurmuş, Ahmet Göktuğ Ertem, Büşra Çolak, Emine Bilen, Göktürk İpek, Tahir Durmaz, Telat Keleş, Engin Bozkurt. Association between carotid intima-media thickness and presence of coronary artery disease in chronic obstructive pulmonary disease patients. Anatol J Cardiol. 2016; 16(8): 601-607

Corresponding Author: Özge Kurmuş, Türkiye


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