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Normal values correlates' of carotid intima- media thickness and affecting parameters in healthy adults [Anatol J Cardiol]
Anatol J Cardiol. 2012; 12(5): 427-433 | DOI: 10.5152/akd.2012.127  

Normal values correlates' of carotid intima- media thickness and affecting parameters in healthy adults

Fahri Halit Beşir1, Sibel Yazgan2, Gökhan Celbek3, Mesut Aydın4, Ömer Yazgan2, Melih Engin Erkan5, Mesut Erbaş6, Adem Güngör3
1Düzce Üniversitesi Tıp Fakültesi Hastanesi, Radyoloji Anabilim Dalı, Konuralp, Düzce-Türkiye
2Düzce Üniversitesi Tıp Fakültesi, Radyoloji Anabilim Dalı, Düzce-Türkiye
3Düzce Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Düzce-Türkiye
4Düzce Üniversitesi Tıp Fakültesi, Kardiyoloji, Anabilim Dalı, Düzce-Türkiye
5Düzce Üniversitesi Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, Düzce-Türkiye
6Düzce Üniversitesi Tıp Fakültesi, Anestezi ve Reanimasyon Anabilim Dalı, Düzce-Türkiye

Objective: Early changes in atherosclerosis can be diagnosed by the carotid artery intima-media thickness (CIMT) measurement. Normal range of CIMT in healthy subjects has not been studied yet in our country. Therefore, the aim of this study was to measure the CIMT in healthy individuals and investigate affecting parameters of CIMT. Methods: Overall, 2298 subjects, aged 18 to 92 years were undergone CIMT measurement in this observational cohort study. 151 healthy adult subjects, aged 20 to 79 year without atherosclerotic risk factors, normal body mass index and normal metabolic parameters were selected to establish normative CIMT values. Correlations between CIMT and atherosclerotic risk factors were evaluated in the Turkish population. The independent variables associated with CIMT were evaluated with multiple linear regression analysis. Results: CIMT value was 0.458±0.116 mm in males and 0.47±0.104 mm in females. Mean values of CIMT (in mm) for healthy reference sample aged 20-29, 30-39, 40-49, 50-59, 60-69 and 70-79 years were 0.402; 0.466; 0.492; 0.586; 0.692 and 0.733, respectively. CIMT increased significantly (p<0.001) by 0.066 mm, in every decade. Correlates of CIMT were age, visceral fat level, fasting serum glucose, total and low-density lipoprotein cholesterol. Multiple linear regression analysis revealed that age was the single independent predictor of CIMT thickness in healthy individuals (β=0.007, 95% CI: 0.006-0.008, p<0.001). Conclusion: CIMT was 0.458±0.116 mm in men and 0.47±0.104 mm in Turkish healthy adults. Age was the only predictor of CIMT. CIMT measurement can be used in the assessment of early atherosclerosis burden in adults

Keywords: Atherosclerosis, carotid artery intima- media thickness (CIMT), normative values, healthy subjects, linear regression analysis


Fahri Halit Beşir, Sibel Yazgan, Gökhan Celbek, Mesut Aydın, Ömer Yazgan, Melih Engin Erkan, Mesut Erbaş, Adem Güngör. Normal values correlates' of carotid intima- media thickness and affecting parameters in healthy adults. Anatol J Cardiol. 2012; 12(5): 427-433


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