ISSN 2149-2263 | E-ISSN 2149-2271
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The Value and Throughput of Rest Thallium-201/Stress Technetium -99m Sestamibi Dual-Isotope Myocardial SPECT [Anatol J Cardiol]
Anatol J Cardiol. 2004; 4(2): 161-168

The Value and Throughput of Rest Thallium-201/Stress Technetium -99m Sestamibi Dual-Isotope Myocardial SPECT

Berna Okudan1, Thomas C. Smitherman2
1Department of Nuclear Medicine, Ankara Numune Research and Training Hospital, Ankara, Turkiye
2Department of Nuclear Cardiology, University of Pittsburgh Medical School, Pittsburgh, USA

Myocardial perfusion scintigraphy is an established method in cardiology for the diagnosis and evaluation of coronary artery disease (CAD). Thallium-201 and Tc-99m sestamibi myocardial perfusion imaging has been widely accepted as non-invasive diagnostic procedure for detection of CAD, risk stratification and myocardial viability assessment. But, standard Tl-201 redistribution and same day or 2-day rest/stress Tc-99m sestamibi protocols are time-consuming. Hence, the dual isotope rest thallium-201/stress technetium-99m sestamibi gated single-photon emission tomography protocol has gained increasing popularity for these applications. Combining the use of thallium-201 with technetium-99m agents permits optimal image resolution and simultaneous assessment of viability. Dual-isotope imaging may be separate or simultaneous acquisition set-up. The more rapid completion of these studies is appreciated as an advantage by patients, technologists, interpreting and referring physicians, nurses and hospital management. Simultaneous imaging has the potential advantages of precise pixel registration and artifacts, if present, are identical in both thallium and sestamibi, and require only one set of imaging. Also, there are some disadvantages of spillover of activity from the Tc-99m to the Tl-201 window. Fortunately, despite this problem it can be overcome. Separate acquisition dual isotope also has some disadvantages. Difference in defect resolution in attenuation and scatter between T-201 and Tc-99m sestamibi potentially results in interpretation problems. But, studies about cost-effectiveness of dual isotope imaging showed that some selective elimination of the rest studies may decrease the cost of the nuclear procedures and should be considered in the current care health system.

Keywords: Dual isotope myocardial imaging-Tl-201-Tc-99m MIBI myocardial SPECT, Rest Tl-201/Stress Tc-99m MIBI

Çift İzotop Miyokardiyal SPECT İstirahat Talyum-201/Stres Teknesyum –99m Sestamibi Değeri ve İşlem Hacmi

Berna Okudan1, Thomas C. Smitherman2
1Department of Nuclear Medicine, Ankara Numune Research and Training Hospital, Ankara, Turkiye
2Department of Nuclear Cardiology, University of Pittsburgh Medical School, Pittsburgh, USA

Anahtar Kelimeler: Dual izotop miyokard görüntüleme, Tl-201-Tc-99m MIBI miyokardial SPECT, İstirahat Tl-201/Stres Tc- 99m MIBI

Berna Okudan, Thomas C. Smitherman. The Value and Throughput of Rest Thallium-201/Stress Technetium -99m Sestamibi Dual-Isotope Myocardial SPECT. Anatol J Cardiol. 2004; 4(2): 161-168
Manuscript Language: English


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