ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 24 Issue : 2
Current Issue Archive Popular Article Ahead of Print

 
Assessment of the Efficacy of Bisoprolol Administration by Cardiopulmonary Exercise Testing in Patients with Heart Failure [Anatol J Cardiol]
Anatol J Cardiol. 2003; 3(4): 313-318

Assessment of the Efficacy of Bisoprolol Administration by Cardiopulmonary Exercise Testing in Patients with Heart Failure

Sait Terzi1, Şennur Ünal Dayi1, Tamer Akbulut1, Ömer Dağ1, Hacer Köse2, Ömer Şatıroğlu3, Nurten Sayar1, Tuba Bilsel1, Şükrü Aksoy1, Kemal Yeşilçimen4
1Dr.Siyami Ersek Göğüs Kalp Damar Cerrahisi, Kardiyoloji Kliniği, İstanbul
2Dr.Siyami Ersek Göğüs Kalp Damar Cerrahisi, Haydarpaşa Numune Hastanesi, İstanbul
3Department of Cardiology, Faculty of Medicine, Rize University, Rize-Turkey
4Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul

Objective: It is well known that long-term therapy with beta-blockers reduces morbidity and mortality, improves left ventricular function in patients with heart failure. However the effect of beta-blockade on exercise tolerance in patients with heart failure remains unclear. In the present study we evaluated effects of the addition of bisoprolol to standart therapy with a diuretic and an angiotensin converting enzyme (ACE) inhibitor on exercise capacity in patients with chronic heart failure. Methods: We enrolled 52 patients (mean age 59±11 years) with stable, mild to moderate chronic heart failure and left ventricular ejection fraction of %40 or less receiving standart therapy with diuretic and ACE inhibitor. We randomly assigned patients to bisoprolol 1.25 mg (n=28) or control (n=24) groups. The drug progressively increased to a maximum dose of 5 mg per day. Cardiopulmonary exercise testing (CPET) was performed in all patients of the bisoprolol and control groups before and after 3 months from the beginning of the study. Results: We found a significant increase in exercise duration, maximal O2 uptake (pik VO2 ), the O2 uptake at the anaerobic threshold (VO2-AT) and O2-pulse (pik VO2/ HR), and improved functional capacity (p<0.001). Bisoprolol produced significant reduction in heart rate at rest (p=0.01) and during maximal exercise (p=0.041). In the control group no significant changes were observed. Conclusion: The addition of bisoprolol to the standart therapy in patients with mild to moderate heart failure is well tolerated and improves functional capacity.

Keywords: Chronic heart failure, bisoprolol, exercise capacity


Sait Terzi, Şennur Ünal Dayi, Tamer Akbulut, Ömer Dağ, Hacer Köse, Ömer Şatıroğlu, Nurten Sayar, Tuba Bilsel, Şükrü Aksoy, Kemal Yeşilçimen. Assessment of the Efficacy of Bisoprolol Administration by Cardiopulmonary Exercise Testing in Patients with Heart Failure. Anatol J Cardiol. 2003; 3(4): 313-318


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share


Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright © 2019 Turkish Society of Cardiology