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β-2 microglobulin level is negatively associated with global left ventricular longitudinal peak systolic strain and left atrial volume [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(11): 844-849 | DOI: 10.14744/AnatolJCardiol.2015.6691  

β-2 microglobulin level is negatively associated with global left ventricular longitudinal peak systolic strain and left atrial volume

Akar Yılmaz1, Banu Yılmaz2, Selçuk Küçükseymen3
1Department of Cardiology, Faculty of Medicine, İzmir University, İzmir-Turkey
2Division of Nephrology, Tepecik Training and Research Hospital, İzmir-Turkey
3Clinic of Cardiology, Antalya Training and Research Hospital, Antalya-Turkey

Objective: There are many factors related to high left atrial volume index (LAVI) and global left ventricular longitudinal peak systolic strain (GLS- %) decline in chronic kidney disease. The purpose of our study is to investigate the relation between the β-2 microglobulin (β-2μ) and GLS-% and LAVI in patients with chronic kidney disease not yet on dialysis.
Methods: Our study was a non-randomized, controlled, prospective study. We included 87 consecutive patients with eGFR levels below 60 ml/ min/m2 not on dialysis and 82 normal healthy individuals with complaints of atypical chest pain and negative stress tests as control group in our study. Patients with hospitalization related to dialysis or heart failure attacks within 3 months, active malignancy, malnutrition, pregnancy, and uncontrolled hypertension were excluded. Brachial pulse wave velocity (PWV), augmentation index, augmentation pressure and central hemodynamics, and PWV analysis were performed in order to assess the arterial stiffness and blood pressure. According to the distribution of data, Spearman and Pearson correlations and multiple linear regression were used to determine significant and independent factor associated with high LAVI and low GLS-%.
Results: There were significant correlations between β-2μ with LAVI (r=0.313, p=0.004) and with GLS-% (r=–0.222, p=0.04). In multiple linear re- gression, the relationship between β-2μ with GLS-% [β=–0.037, 95% CI (–0.062, –0.013), p=0.004] and LAVI [β=4.522, 95% CI (2.806, 6.238), p<0.001] was independent of age, PWV, central and peripheral blood pressures, parathormone, CalciumXPhospor, Hgb levels, and eGFR.
Conclusion: Increasing β-2μ levels were found to be associated with increased LAVI and decreased GLS-%. Additional experimental studies are needed to clarify these relationships. (Anatol J Cardiol 2016; 16: 844-9)

Keywords: cardiac dysfunction, beta-2 microglobulin, chronic kidney disease, global longitudinal strain, left atrial volume index


Akar Yılmaz, Banu Yılmaz, Selçuk Küçükseymen. β-2 microglobulin level is negatively associated with global left ventricular longitudinal peak systolic strain and left atrial volume. Anatol J Cardiol. 2016; 16(11): 844-849

Corresponding Author: Akar Yılmaz, Türkiye


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