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The effect of rutin on cisplatin-induced oxidative cardiac damage in rats [Anatol J Cardiol]
Anatol J Cardiol. 2018; 20(3): 136-142 | DOI: 10.14744/AnatolJCardiol.2018.32708  

The effect of rutin on cisplatin-induced oxidative cardiac damage in rats

Ismail Topal1, Aslı Özbek Bilgin5, Ferda Keskin Çimen6, Nezahat Kurt2, Zeynep Süleyman3, Yasin Bilgin4, Adalet Özçiçek7, Durdu Altuner5
1Department of Pediatrics, Neon Hospital; Erzincan-Turkey
2Department of Biochemistry, Faculty of Medicine, Atatürk University; Erzurum-Turkey
3Department of Nursing, Faculty of Health Sciences, Erzincan University; Erzincan-Turkey
4Department of Emergency, Mengücek Gazi Training and Research Hospital; Erzincan-Turkey
5Department of Pharmacology, Faculty of Medicine, Erzincan University; Erzincan-Turkey
6Department of Pathology, Faculty of Medicine, Erzincan University; Erzincan-Turkey
7Department of Internal Medicine, Faculty of Medicine, Erzincan University; Erzincan-Turkey

Objective: Cisplatin is an anticancer drug used for treating childhood solid tumors. Symptoms related to cisplatin-induced cardiovascular adverse effects may be mild or severe. Rutin (vitamin P1) has many properties, including as antioxidant, anticancer, antidiabetic, antimicrobial, antiulcer, and tissue renewal properties. Therefore, we aimed to biochemically, histopathologically, and immunohistochemically demonstrate the effect of rutin on cisplatin-induced cardiotoxicity in rats.
Methods: The rats included in our study were divided into four groups: Healthy group (HE), 5-mg/kg cisplatin group (CP), 50 mg/kg rutin+5-mg/kg cisplatin (CR-50), 100-mg/kg rutin+5-mg/kg cisplatin (CR-100) group.
Results: CP group administered cisplatin had significantly increased blood, serum, and cardiac tissue malondialdehyde (MDA), interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), troponin I, creatine kinase (CK), and CK-MB levels compared to the HE group, whereas there was a significant decrease in the total glutathione (tGSH) levels. Rutin was observed to prevent the increase in MDA, IL-1β, TNF-α, troponin I, CK, and CK-MB levels as well as prevent the decrease in tGSH levels more significantly when administered at a 100-mg/kg dose than at a 50-mg/kg dose. Histopathologically, cardiac necrosis, dilated/congested blood vessels, hemorrhage, polymorphonuclear leukocyte, edema, and cells with pyknotic nuclei were observed in the CP group. Rutin was shown to prevent cisplatin-induced cardiac damage more effectively when used at a100-mg/kg dose than at a 50-mg/kg dose.
Conclusion: These results suggest that rutin is useful for preventing cisplatin-related cardiovascular damage.

Keywords: cisplatin, cardiac damage, rutin, rat


Ismail Topal, Aslı Özbek Bilgin, Ferda Keskin Çimen, Nezahat Kurt, Zeynep Süleyman, Yasin Bilgin, Adalet Özçiçek, Durdu Altuner. The effect of rutin on cisplatin-induced oxidative cardiac damage in rats. Anatol J Cardiol. 2018; 20(3): 136-142

Corresponding Author: Durdu Altuner, Türkiye


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