ISSN 2149-2263 | E-ISSN 2149-2271
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Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases [Anatol J Cardiol]
Anatol J Cardiol. 2012; 12(8): 684-688 | DOI: 10.5152/akd.2012.221

Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases

İlker Taşçı1, Hasan Kutsi Kabul2, Aydoğan Aydoğdu3
1Department of Internal Medicine, Gülhane School of Medicine, Ankara-Turkey
2Department of Cardiology, Gülhane School of Medicine, Ankara-Turkey
3Department of Endocrinology and Metabolism, Gülhane School of Medicine, Ankara-Turkey

Important advances in our understanding of the relationships between adipose tissue derived peptides, namely adipokines, and their effects on cardiovascular functions have been achieved in recent years. Growing knowledge of adipokine biology is revealing the complexity of these proteins. Adipose tissue releases some other proteins called neurotrophins that are mainly active in central and peripheral nervous system. However, secretion and activity of these hormones are not only limited to neuronal cells and tissues, but they also take part in adipose tissue development, energy metabolism, glucose utilization, insulin sensitivity, inflammation, lipoprotein synthesis, and atherosclerosis. In this review, we describe the most recent advances in the functions of brain derived nerve growth factor (BDNF), a major type of neurotrophins, focusing primarily on cardiovascular and metabolic diseases.

Keywords: Brain derived nerve growth factor, cardiovascular disease, atherosclerosis, dyslipidemia, diabetes mellitus

İlker Taşçı, Hasan Kutsi Kabul, Aydoğan Aydoğdu. Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases. Anatol J Cardiol. 2012; 12(8): 684-688
Manuscript Language: English


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