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Nebivolol prevents remodeling in a rat myocardial infarction model: an echocardiographic study [Anatol J Cardiol]
Anatol J Cardiol. 2010; 10(1): 18-27

Nebivolol prevents remodeling in a rat myocardial infarction model: an echocardiographic study

Güldem Olguner Mercanoğlu1, Burak Pamukçu2, Nurhas Safran3, Fehmi Mercanoğlu2, Francesco Fici4, Mehmet Güngör5
1Department of Pharmacology Faculty of Pharmacy, Yeditepe University, İstanbul
2Department of Cardiology İstanbul Medical Faculty, İstanbul University, İstanbul, Turkey
32Department of Microbiology, İstanbul Medical Faculty, İstanbul University, İstanbul, Turkey
4Department of Experimental Medicine, Excellence Research Center for Cardiovascular Disease, 2nd University of Naples, Naples, Italy
5Department of Pharmacology and Clinical Pharmacology, İstanbul Medical Faculty, İstanbul University, İstanbul, Turkey

Ob jec ti ve: Ventricular remodeling (VR) which develops after myocardial infarction (MI) plays an important role in progressive left ventricular dysfunction. We aimed to investigate the role of nebivolol treatment on VR after a MI in a rat ischemia-reperfusion model. Methods: Rats were divided into 3 groups of 12 each: sham operated (sham-control), MI-induced (MI-control) and nebivolol treated (MI-nebivolol). Left ventricular (LV) diameters, volumes, and diastolic filling parameters were evaluated by echocardiography. On the 28th day, after recording the systemic and LV pressures and determining the plasma nitric oxide (NO) and peroxynitrite (ONOO-) levels, animals were sacrificed and heart, body and LV weights (HW, BW, LVW) were measured and infarct sizes were determined. Results were evaluated statistically by ANOVA for repeated measurements 3x3 factorial design with post-hoc Bonferroni test. Results: After MI, while VR (an increase in LV diameters and volumes associated with a decrease in EF, FS and posterior wall thickness change (LWPc) was significant in MI-control rats (p<0.05 for; all comparisons) these changes were significantly less in MI-nebivolol group (p=0.08 and p=0.06 for EF and FS respectively). LV end diastolic pres-sure (LVEDP) was lower (p<0.005) and Δ±dp/dt’s (p<0.05) were higher in MI-nebivolol group compared to MI-control animals. Although infarct sizes were similar in MI-induced groups (p=0.79); LVW/HW and HW/BW’s were significantly greater in the MI-control group compared to sham-control (p<0.01 for all comparisons), these changes were not statistically significant in MI-nebivolol group. The increase in plasma NO and ONOO- levels were also prevented with nebivolol. Conclusion: Nebivolol therapy reduced the effects of VR in rats after MI. These beneficial effects were not related to its heart rate and blood pressure reducing effects. Nitric oxide regulatory action of this compound may contribute these beneficial effects on VR developed after MI.

Keywords: Myocardial infarction, ventricular remodeling, nebivolol, echocardiography, nitric oxide, peroxynitrite, left ventricular function


Güldem Olguner Mercanoğlu, Burak Pamukçu, Nurhas Safran, Fehmi Mercanoğlu, Francesco Fici, Mehmet Güngör. Nebivolol prevents remodeling in a rat myocardial infarction model: an echocardiographic study. Anatol J Cardiol. 2010; 10(1): 18-27


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