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New fully automated software for assessment of brachial artery flow- mediated dilation with advantages of continuous measurement [Anatol J Cardiol]
Anatol J Cardiol. 2012; 12(7): 553-559 | DOI: 10.5152/akd.2012.190  

New fully automated software for assessment of brachial artery flow- mediated dilation with advantages of continuous measurement

Ertuğrul Ercan1, Bahadır Kırılmaz2, İsmail Kahraman3, Vildan Bayram3, Hüseyin Doğan2
1Clinic of Cardiology, Medikal Park İzmir Hospital, İzmir-Turkey
2Department of Cardiology, Faculty of Medicine Çanakkale Onsekiz Mart University, Çanakkale-Turkey
3Department of Computer Engineering, Faculty of Engineering, Çanakkale Onsekiz Mart University, Çanakkale-Turkey

Objective: Flow-mediated dilation (FMD) is used to evaluate endothelial functions. Computer-assisted analysis utilizing edge detection permits continuous measurements along the vessel wall. We have developed a new fully automated software program to allow accurate and reproducible measurement. Methods: FMD has been measured and analyzed in 18 coronary artery disease (CAD) patients and 17 controls both by manually and by the software developed (computer supported) methods. The agreement between methods was assessed by Bland-Altman analysis. Results: The mean age, body mass index and cardiovascular risk factors were higher in CAD group. Automated FMD% measurement for the control subjects was 18.3±8.5 and 6.8±6.5 for the CAD group (p=0.0001). The intraobserver and interobserver correlation for automated measurement was high (r=0.974, r=0.981, r=0.937, r=0.918, respectively). Manual FMD% at 60th second was correlated with automated FMD % (r=0.471, p=0.004). Conclusions: The new fully automated software© can be used to precise measurement of FMD with low intra- and interobserver variability than manual assessment.

Keywords: Flow mediated dilation, endothelial function, reliability and validity


Ertuğrul Ercan, Bahadır Kırılmaz, İsmail Kahraman, Vildan Bayram, Hüseyin Doğan. New fully automated software for assessment of brachial artery flow- mediated dilation with advantages of continuous measurement. Anatol J Cardiol. 2012; 12(7): 553-559


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