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A current problem in atherothrombotic diseases - aspirin resistance: Definition, mechanisms, determination with laboratory tests and clinical implications [Anatol J Cardiol]
Anatol J Cardiol. 2007; 7(Suppl 2): 20-26

A current problem in atherothrombotic diseases - aspirin resistance: Definition, mechanisms, determination with laboratory tests and clinical implications

Burak Pamukçu1, Hüseyin Oflaz2, Yılmaz Nişancı3
1Department of Cardiology İstanbul Medical Faculty, İstanbul University, İstanbul, Turkey
2Department of Cardiology, İstanbul Faculty of Medicine, İstanbul University, İstanbul-Turkey
3İstanbul Üniversitesi Çapa Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul-Türkiye

Aspirin (acetylsalicylic acid) is a powerful antiplatelet agent used in prevention of atherothrombotic vascular events. However, antiplatelet effect of aspirin is not uniform and some patients could not benefit from aspirin. These patients are clinically called as aspirin resistant or aspirin non-responders. Aspirin resistance could be determined by: bleeding time, optical aggregometry, PFA-100 (Platelet Function Analyzer), Ultegra-RPFA (Rapid Platelet Function Assay), activated aggregation time, whole blood aggregometry, platelet aggregate ratio, flow cytometry, measurements of platelet surface proteins and blood or urine thromboxane B2 levels. Mechanisms of aspirin resistance have not been elucidated yet. There is evidence that aspirin resistance increases clinical cardiovascular events. Adequate additional therapies may reduce atherothrombotic risks and major cardiovascular events rate in aspirin resistant subjects. However, we need further studies to decrease major cardiovascular events risk in aspirin resistant subjects and to optimize antiplatelet therapy.

Keywords: Aspirin, aspirin resistance, platelet function tests


Aterotrombotik hastalıklarda güncel bir sorun - aspirin direnci: Tanımı, oluşum mekanizmaları, laboratuvar yöntemleri ile belirlenmesi ve klinik sonuçları

Burak Pamukçu1, Hüseyin Oflaz2, Yılmaz Nişancı3
1Department of Cardiology İstanbul Medical Faculty, İstanbul University, İstanbul, Turkey
2Department of Cardiology, İstanbul Faculty of Medicine, İstanbul University, İstanbul-Turkey
3İstanbul Üniversitesi Çapa Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul-Türkiye

Anahtar Kelimeler: Aspirin, aspirin direnci, platelet fonksiyon testleri


Burak Pamukçu, Hüseyin Oflaz, Yılmaz Nişancı. A current problem in atherothrombotic diseases - aspirin resistance: Definition, mechanisms, determination with laboratory tests and clinical implications. Anatol J Cardiol. 2007; 7(Suppl 2): 20-26


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