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N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study [Anatol J Cardiol]
Anatol J Cardiol. 2011; 11(4): 305-309 | DOI: 10.5152/akd.2011.080  

N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study

Mehmet Özaydın1, Doğan Erdoğan2, Şenol Tayyar1, Bayram Ali Uysal1, Abdullah Doğan1, Atilla İçli1, Emel Özkan3, Ercan Varol2, Yasin Türker4, Akif Arslan1
1Department of Cardiology, Faculty of Medicine, Süleyman Demirel University, Isparta
2Department of Cardiology Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey
3Department of Cardiology, Gülkent State Hospital, Isparta-Turkey
4Süleyman Demirel Üniversitesi Tıp Fakültesi, Kardiyoloji Ana Bilim Dalı Isparta, Türkiye

Objective: The purpose of the present prospective randomized study was to evaluate the effects of n-3 polyunsaturated fatty acids on recurrence rates of atrial fibrillation (AF) and inflammation after electrical cardioversion. Methods: Calculation of the number of patients needed was based on the assumption of 20% and 65% chance of maintaining sinus rhythm with amiodarone and with polyunsaturated fatty acids, respectively. To observe a significant difference with an alpha level of 0.05 and a power of 0.80 it was necessary to include 22 patients in each group. A total of 47 patients were randomized to amiodarone (n=24) and amiodarone plus n-3 polyunsaturated fatty acids (n=23) groups before scheduled electrical cardioversion. The end-point was the recurrence of AF during 12-month follow-up. Effect of n-3 polyunsaturated fatty acids on inflammation was evaluated with high sensitivity C-reactive protein level measurements. Statistical analysis was performed using unpaired Student’ t, Mann Whitney U and Chi-square tests. We analyzed the recurrence of AF using the Cox proportional hazards regression model to control for potentially confounding factors. Results: Nine patients in the amiodarone group (37.5%), and 9 patients in the amiodarone plus n-3 polyunsaturated fatty acids group (39.1%) had recurrence of AF during follow-up (p=1). With the Cox proportional model, risk factors for the recurrence of AF were previous electrical cardioversion (HR 10.33, 95% CI 1.74 to 61.10, p=0.01) and high sensitivity C-reactive protein levels (HR 1.07, 95% CI 1.02 to 1.38, p=0.007). High sensitivity C-reactive protein levels at baseline, at day 15 and during AF recurrence were similar between two groups (p > 0.05 for all). Conclusion: N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation.

Keywords: Atrial fibrillation, recurrence, polyunsaturated fatty acids, Cox proportional regression analysis


Mehmet Özaydın, Doğan Erdoğan, Şenol Tayyar, Bayram Ali Uysal, Abdullah Doğan, Atilla İçli, Emel Özkan, Ercan Varol, Yasin Türker, Akif Arslan. N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study. Anatol J Cardiol. 2011; 11(4): 305-309


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