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Visit-to-visit variability in LDL-cholesterol is associated with adverse events in non-obstructive coronary artery disease [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-26428 | DOI: 10.14744/AnatolJCardiol.2019.26428  

Visit-to-visit variability in LDL-cholesterol is associated with adverse events in non-obstructive coronary artery disease

Jun Gu, Zhao-fang Yin, Jian-an Pan, Jun-feng Zhang, Changqian Wang
Department of Cardiology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine

Objective: Higher visit-to-visit variability in low-density lipoprotein cholesterol (LDL-C) is associated with increased cardiovascular events. We investigated the association between visit-to-visit LDL-C variability with all-cause mortality, myocardial infarction (MI) and coronary revascularization in non-obstructive coronary artery disease (CAD) population.
Methods: Among this retrospective cohort of individuals who underwent coronary angiography from 2006 to 2010, 2012 consecutive non-obstructive CAD patients, undergone 3 or more LDL-C determinations during the first 2 years, were identified and followed up for 5 years. Variability in visit-to-visit LDL-C was measured by standard deviation (SD) and coefficient of variation (CV). Risks of all-cause mortality and composite of mortality, MI and coronary revascularization were evaluated by multivariable Cox regression analysis.
Results:During a 5-year follow-up, 99 (4.92%) mortality cases and 154 (7.65%) cases of composite endpoints were observed. The percentage of subjects who experienced mortality or composite endpoints was higher in those with higher LDL-C-SD or LDL-C-CV level. Association between LDL-C variability and clinical endpoints was regardless of possible confounding factors.
Conclusions: Among the patients with non-obstructive CAD, higher visit-to-visit LDL-C variability is associated with increasing all-cause mortality or composite endpoints during the long-term follow-up.

Keywords: coronary artery disease, low-density lipoprotein, cholesterol, variability, cardiovascular outcomes


Visit-to-visit variability in LDL-cholesterol is associated with adverse events in non-obstructive coronary artery disease

Jun Gu, Zhao-fang Yin, Jian-an Pan, Jun-feng Zhang, Changqian Wang
Department of Cardiology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine

Objective: Higher visit-to-visit variability in low-density lipoprotein cholesterol (LDL-C) is associated with increased cardiovascular events. We investigated the association between visit-to-visit LDL-C variability with all-cause mortality, myocardial infarction (MI) and coronary revascularization in non-obstructive coronary artery disease (CAD) population.
Methods: Among this retrospective cohort of individuals who underwent coronary angiography from 2006 to 2010, 2012 consecutive non-obstructive CAD patients, undergone 3 or more LDL-C determinations during the first 2 years, were identified and followed up for 5 years. Variability in visit-to-visit LDL-C was measured by standard deviation (SD) and coefficient of variation (CV). Risks of all-cause mortality and composite of mortality, MI and coronary revascularization were evaluated by multivariable Cox regression analysis.
Results:During a 5-year follow-up, 99 (4.92%) mortality cases and 154 (7.65%) cases of composite endpoints were observed. The percentage of subjects who experienced mortality or composite endpoints was higher in those with higher LDL-C-SD or LDL-C-CV level. Association between LDL-C variability and clinical endpoints was regardless of possible confounding factors.
Conclusions: Among the patients with non-obstructive CAD, higher visit-to-visit LDL-C variability is associated with increasing all-cause mortality or composite endpoints during the long-term follow-up.

Anahtar Kelimeler: coronary artery disease, low-density lipoprotein, cholesterol, variability, cardiovascular outcomes




Corresponding Author: Changqian Wang, China


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