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The effect of interleukin-10 gene promoter polymorphisms on early-onset coronary artery disease [Anatol J Cardiol]
Anatol J Cardiol. 2011; 11(4): 285-289 | DOI: 10.5152/akd.2011.077  

The effect of interleukin-10 gene promoter polymorphisms on early-onset coronary artery disease

Emin Karaca1, Meral Kayıkçıoğlu2, Hüseyin Onay1, Cumhur Gündüz3, Ferda Özkınay1
1From Department Medical Genetics, Faculty of Medicine, Ege University, Izmir-Turkey
2Ege Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye
3From Department Medical Biology Faculty of Medicine, Ege University, Izmir-Turkey

Objective: We assessed the association between interleukin-10 (IL-10) -1082G/A and -592C/A polymorphisms, and coronary heart disease (CHD). Methods: A cross-sectional, observational study included 86 patients (mean age 43.36±4.930 years) diagnosed to have CHD and 88 healthy controls (mean age 47.07±8.135 years). IL-10 -1082G/A and -592C/A polymorphisms were analyzed using restriction fragment length polymorphism (RFLP) and agarose gel electrophoresis methods in both patient and control groups. Genotype distributions of the polymorphisms between CHD patients and controls were assessed by Chi-square analysis. Results: The genotype distribution of the -1082 G/A polymorphism was not different in premature CHD patients (GG: 38.3%; GA: 51.1%; AA: 10.6%) and controls (GG: 43.1%; GC: 43.1%; CC: 13.8%) (p=0.57). The prevalence of the A allele at -1082G/A polymorphism was 36.6% in patients and 35.3% in controls. Both allele and genotype frequencies of -592C/A polymorphism did not also differ significantly between patients with CHD and controls. We did not observe relationships between polymorphism-specific haplotypes and adverse angiographic and clinical outcomes. We have observed a significant difference of IL-10 -592C/A allelic frequency (OR=2.00 95% CI=0.9434-4.2579) between the younger CHD patients (<45 years, Group 2) and matched controls. Conclusion: Our study suggests that IL-10-592C/A polymorphism may play a role in susceptibility to CHD in younger patients.

Keywords: Interleukin-10, promoter polymorphisms, coronary heart disease, prevalence


Emin Karaca, Meral Kayıkçıoğlu, Hüseyin Onay, Cumhur Gündüz, Ferda Özkınay. The effect of interleukin-10 gene promoter polymorphisms on early-onset coronary artery disease. Anatol J Cardiol. 2011; 11(4): 285-289


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