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Interleukin-25 increases in human coronary artery disease and is associated with the severity of coronary stenosis [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-24265 | DOI: 10.14744/AnatolJCardiol.2019.24265  

Interleukin-25 increases in human coronary artery disease and is associated with the severity of coronary stenosis

Yao Xu, Jing Ye, Menglong Wang, Jianfang Liu, Zhen Wang, Huimin Jiang, Di Ye, Jishou Zhang, Jun Wan
Department of Cardiology, Renmin Hospital of Wuhan University; Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology, Wuhan, China

Objective: Interleukin (IL) 25, also known as IL-17E, is an inflammatory cytokine and has been demonstrated to be closely related to cardiovascular diseases by regulating immunity and inflammation, including atherosclerosis. This study was aimed to evaluate the IL-25 expression in patients with coronary artery disease (CAD).
Methods: In this study, IL-25 expression in normal (n=6) and atherosclerotic (n=10) human coronary arteries was detected by immunofluorescent staining. In addition, the serum IL-25, IL-6 and tumor necrosis factor (TNF) α concentrations in stable angina pectoris (SAP, n=44), unstable angina pectoris (UAP, n=46), acute myocardial infarction (AMI, n=34) and non-CAD (control, n=36) were measured by enzyme-linked immunosorbent assay (ELISA) kits.
Results: IL-25 was significantly increased in coronary arteries of CAD patients when compared with normal coronary arteries, with macrophages and T lymphocytes being the sources of IL-25, especially macrophages. Moreover, the serum concentrations of IL-25 were markedly elevated in CAD patients and gradually increased in SAP, UAP and AMI groups. In addition, IL-25 levels were positively correlated with the IL-6, TNF-α and Gensini Score in CAD patients. Linear regression analysis showed that IL-25 was independent positively correlated with the occurrence of acute coronary syndrome (ACS). Receiver operator characteristic curve suggested that IL-25 presented a more significant diagnosis value than cTnI did in ACS while combining the three cytokines presented the best.
Conclusion: IL-25 is increased in the coronary arteries and serum of CAD patients. and associated with the severity of coronary stenosis and the occurrence of ACS, suggesting that IL-25 may be one of biomarker of ACS.

Keywords: Interleukin 25, Coronary artery disease, Inflammation, Gensini Score

Corresponding Author: Jun Wan, China

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