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The expression of interleukin-25 increases in human coronary artery disease and is associated with the severity of coronary stenosis [Anatol J Cardiol]
Anatol J Cardiol. 2020; 23(3): 151-159 | DOI: 10.14744/AnatolJCardiol.2019.24265  

The expression of interleukin-25 increases in human coronary artery disease and is associated with the severity of coronary stenosis

Yao Xu, Jing Ye, Menglong Wang, Jianfang Liu, Zhen Wang, Huimin Jiang, Di Ye, Jishou Zhang, Jun Wan
Department of Cardiology, Renmin Hospital of Wuhan University; Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology; Wuhan-China

Objective: Interleukin (IL) 25, also known as IL-17E, is an inflammatory cytokine and has been demonstrated to be closely related to cardiovascular diseases by regulating immunity and inflammation, including atherosclerosis. This study was aimed to evaluate the expression of IL-25 in patients with coronary artery disease (CAD).
Methods: In this study, the expression of IL-25 in normal (n=6) and atherosclerotic (n=10) human coronary arteries was detected by immunofluorescent staining. In addition, the serum IL-25, IL-6, and tumor necrosis factor (TNF) α concentrations in stable angina pectoris (SAP, n=44), unstable angina pectoris (UAP, n=46), acute myocardial infarction (AMI, n=34), and non-CAD (control, n=36) were measured using enzyme-linked immunosorbent assay (ELISA) kits.
Results: IL-25 was significantly increased in coronary arteries of CAD patients when compared with normal coronary arteries, with macrophages and T lymphocytes being the sources of IL-25, especially macrophages. Moreover, the serum concentrations of IL-25 were markedly elevated in CAD patients and gradually increased in SAP, UAP, and AMI groups. In addition, IL-25 levels were positively correlated with the IL-6 and TNF-α levels, and Gensini score in CAD patients. Logistic regression analysis showed that IL-25 was independently positively correlated with the occurrence of acute coronary syndrome (ACS). A receiver operator characteristic curve suggested that IL-25 presented a significant diagnosis value in ACS.
Conclusion: IL-25 is increased in the coronary arteries and serum of CAD patients and is associated with the severity of coronary stenosis and the occurrence of ACS, suggesting that IL-25 may be one of the biomarkers of ACS.

Keywords: interleukin 25, coronary artery disease, inflammation, Gensini score


Yao Xu, Jing Ye, Menglong Wang, Jianfang Liu, Zhen Wang, Huimin Jiang, Di Ye, Jishou Zhang, Jun Wan. The expression of interleukin-25 increases in human coronary artery disease and is associated with the severity of coronary stenosis. Anatol J Cardiol. 2020; 23(3): 151-159

Corresponding Author: Jun Wan, China


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