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Beyond lowering LDL cholesterol [Anatol J Cardiol]
Anatol J Cardiol. 2011; 11(2): 163-167 | DOI: 10.5152/akd.2011.039  

Beyond lowering LDL cholesterol

Özgür Bayturan1, Ozan Ütük2, Murat Tuzcu3
1Celal Bayar Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Manisa, Türkiye
2Department of Cardiology, School of Medicine, Celal Bayar University, Manisa, Turkey
3Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland OH, USA

Compelling evidence from randomized controlled studies demonstrated the crucial role of lowering low-density lipoprotein cholesterol (LDL-C) in the prevention of vascular events. However, not all patients with low LDL-C levels show similar reduction in event rates. The residual risk factors associated with ongoing vascular events despite achieving low LDL-C levels remain to be elucidated. New data suggest that beyond statin therapy, inflammatory mediators, high non-HDL (high-density lipoprotein) cholesterol or apolipoprotein B, small dense LDL-C, type 2 diabetes mellitus, and lifestyle features may have impact on residual vascular risk. In this review, we discussed the significance of identifying these residual risk factors and developing new treatment strategies to further decrease vascular events. The importance of imaging arterial wall to evaluate the effect of various medical therapies has also stated.

Keywords: Residual risk, LDL, atherogenic dyslipidemia, apolipoprotein B

Özgür Bayturan, Ozan Ütük, Murat Tuzcu. Beyond lowering LDL cholesterol. Anatol J Cardiol. 2011; 11(2): 163-167

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