ISSN 2149-2263 | E-ISSN 2149-2271
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Relationship of brain natriuretic peptide with metabolic syndrome parameters: an observational study [Anatol J Cardiol]
Anatol J Cardiol. 2011; 11(8): 678-684 | DOI: 10.5152/akd.2011.188

Relationship of brain natriuretic peptide with metabolic syndrome parameters: an observational study

Sanem Öztekin1, Özlem Karakurt Arıtürk2, Nuray Yazıhan3, İlker Ünal4
1Clinic of Internal Medicine, Nallıhan State Hospital, Ankara
2Clinic of Cardiology, Balıkesir State Hospital, Balıkesir-Turkey
3Department of Pathophysiology, Faculty of Medicine, Ankara University, Ankara-Turkey
4Department of Biostatistics, Faculty of Medicine, Çukurova University, Adana

Objective: Metabolic syndrome (MS) was independently associated with increased risk of incident heart failure and coronary artery disease. In this study, we sought to identify whether there is an association between metabolic syndrome components and left ventricular diastolic functions and brain natriuretic peptide (BNP) levels. Methods: This study is a cross-sectional, observational study. Two hundred consecutive patients with MS were selected to form the study population. Echocardiographic parameters and BNP were determined. Mann-Whitney U test and Kruskal-Wallis test were used to compare BNP levels in categorical variables. Spearman rank correlation analysis was used to investigate the correlation between BNP level and other numerical variables. Linear regression analysis was used to find the variables affecting the BNP level. Results: BNP level was higher in females than males [11.14 (0.12-87) vs 7.49 (0.01-99) pg/dl, p=0.04]. None of the MS parameters affects the BNP level in MS patients. MS criteria number that the patient had was not related to BNP level. Sixty seven percent of patients had left ventricular (LV) diastolic dysfunction. BNP was independent from LV diastolic function. Multiple linear regression analysis demonstrated that having diabetes mellitus increases BNP level by 7.73 unit (β=7.73, 95% CI - 2.321 - 13.149, p=0.006). Conclusion: None of the MS parameters affects the BNP level in MS patients. Diastolic dysfunction existence did not affect the BNP level of MS patients. There is an association between diabetes mellitus and BNP, independent of left ventricle diastolic functions.

Keywords: Brain natriuretic peptide, metabolic syndrome, diastolic dysfunction, regression analysis

Sanem Öztekin, Özlem Karakurt Arıtürk, Nuray Yazıhan, İlker Ünal. Relationship of brain natriuretic peptide with metabolic syndrome parameters: an observational study. Anatol J Cardiol. 2011; 11(8): 678-684
Manuscript Language: English


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