ISSN 2149-2263 | E-ISSN 2149-2271
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Assessment of longitudinal left ventricular systolic function by different echocardiographic modalities in patients with newly diagnosed mild-to-moderate hypertension [Anatol J Cardiol]
Anatol J Cardiol. 2010; 10(3): 247-252 | DOI: 10.5152/akd.2010.065

Assessment of longitudinal left ventricular systolic function by different echocardiographic modalities in patients with newly diagnosed mild-to-moderate hypertension

Dursun Atılgan1, Ahmet Kaya Bilge1, İmran Onur1, Burak Pamukçu2, Mustafa Özcan1, Kamil Adalet1
1Department of Cardiology, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
2Department of Cardiology İstanbul Medical Faculty, İstanbul University, İstanbul, Turkey

Objective: Standard echocardiographic methods reflect chamber dynamics and do not provide a direct measure of myocardial fiber shortening. Therefore we evaluated longitudinal left ventricular myocardial function by tissue Doppler echocardiography; strain (S), strain rate (SR), tissue Doppler velocity (TDV) in newly diagnosed mild to moderate hypertensive patients. Methods: Our cross-sectional and observational study population consisted of 57 patients and 48 normotensive control subjects. Patients with obesity, diabetes mellitus, regional wall motion abnormality, secondary hypertension and a history or clinical evidence of cardiovascular disease, arrhythmias or conduction abnormalities were excluded from the study. Ejection fraction, endocardial fractional shortening (eFS), meridional end-systolic stress (mESS), stress-adjusted eFS (observed /predicted eFS) were measured by M-mode echocardiography. Relationship between the left ventricular mass index and mESS was assessed by Pearson’s linear regression model. Results: Hypertensive patients had significantly decreased longitudinal myocardial function compared to control subjects determined by septal (-1.25±0.30 vs. -1.02±0.33, p<0.001) and lateral (-1.20±0.28 vs. 1.02±0.41, p<0.01) SR (1/s) measurements. However, there was no significant correlation between the mESS and strain-strain rate measurements in both normal and hypertensive subjects. Conclusions: Early impairment in longitudinal left ventricular systolic function can be expected despite normal endocardial left ventricular function indicated by M-mode echocardiography in patients with newly diagnosed and never treated mild to moderate hypertension.

Keywords: Longitudinal myocardial function, strain, strain rate, hypertension

Dursun Atılgan, Ahmet Kaya Bilge, İmran Onur, Burak Pamukçu, Mustafa Özcan, Kamil Adalet. Assessment of longitudinal left ventricular systolic function by different echocardiographic modalities in patients with newly diagnosed mild-to-moderate hypertension. Anatol J Cardiol. 2010; 10(3): 247-252
Manuscript Language: English


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