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Cardiovascular consequences of sleep apnea: II-Cardiovascular mechanisms [Anatol J Cardiol]
Anatol J Cardiol. 2010; 10(2): 168-175 | DOI: 10.5152/akd.2010.044  

Cardiovascular consequences of sleep apnea: II-Cardiovascular mechanisms

Yelda Turgut Çelen1, Yüksel Peker2
1Sleep Medicine Unit, Department of Neurology and Rehabilitation Medicine, Skaraborg Hospital, Skövde
2Sleep Medicine Unit, Department of Neurology and Rehabilitation Medicine, Skaraborg Hospital, Skövde University of Gothenburg, Gothenburg, Sweden

Obstructive sleep apnea (OSA) is a common disorder with serious cardiovascular consequences. The pathogenesis in this context is likely to be multifactorial process including large negative swings in intrathoracic pressure, intermittent hypoxemia and hypercapnia, increased sympathetic nervous system activity, vascular endothelial dysfunction, oxidative stress, systemic inflammation, excessive platelet activation as well as metabolic dysregulation. Although there is scientific support for a considerable impact of OSA on vascular structure and function, it is likely that development of cardiovascular diseases is determined by multiple genotypic and phenotypic factors. The current article focuses on the available research evidence addressing the cardiovascular mechanisms in this context.

Keywords: Obstructive sleep apnea, cardiovascular diseases


Yelda Turgut Çelen, Yüksel Peker. Cardiovascular consequences of sleep apnea: II-Cardiovascular mechanisms. Anatol J Cardiol. 2010; 10(2): 168-175


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