ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 22 Issue : 2
Current Issue Archive Popular Article Ahead of Print

   
Quick Search





 
Chemerin is not associated with subclinical atherosclerosis markers in prediabetes and diabetes [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(10): 749-755 | DOI: 10.5152/AnatolJCardiol.2015.6629  

Chemerin is not associated with subclinical atherosclerosis markers in prediabetes and diabetes

Kadriye Aydın1, Uğur Canpolat2, Şafak Akın1, Muhammet Dural2, Jale Karakaya3, Kudret Aytemir2, Necla Özer2, Alper Gürlek1
1Departments Of Endocrinology And Metabolism, Hacettepe University, Ankara- Turkey
2Cardiology, Hacettepe University, Ankara- Turkey
3Biostatistics, Faculty Of Medicine, Hacettepe University, Ankara- Turkey

Objective: Chemerin is a novel adipokine that is correlated with adipocyte differentiation, glucose metabolism, and inflammation. We aimed to investigate the relation between serum chemerin level and subclinical atherosclerosis markers as exemplified by brachial artery pulse wave velocity (baPWV), carotid intima–media thickness (CIMT), epicardial fat thickness (EFT), and carotid plaque presence in diabetes and prediabetes.
Methods: Age-, body mass index (BMI)-, and gender-matched patients with type 2 DM (n=30), prediabetes (n=25), and normal glucose tolerance (n=25) were included in this cross-sectional study. Serum chemerin level, lipid parameters, glucose metabolism marker, baPWV, CIMT, EFT, and anthropometric were recorded. The independent risk factors for atherosclerosis markers were determined by linear and/or multiple logistic regression analysis.
Results: baPWV and carotid plaque presence were higher in the diabetes group than in prediabetes and control groups (p=0.039 and p=0.035 respectively), whereas serum chemerin levels were similar among groups (p=0.338). Chemerin levels were not correlated with PWV, CIMT, and epicardial fat thickness overall or in the subgroups. Overall and in the diabetes group, chemerin levels were positively correlated with the key components of metabolic syndrome as BMI, total body fat percentage, waist circumference, triglyceride, and systolic and diastolic blood pressure (BP). After adjusting for age, gender, and BMI, only the association between chemerin and systolic BP remained significant. Chemerin was not found as an independent risk factor for predicting atherosclerosis in diabetes and prediabetes.
Conclusion: Chemerin is not a predictive marker for atherosclerosis in diabetes and prediabetes, but correlates well with key aspects of the metabolic syndrome particularly in diabetes. (Anatol J Cardiol 2016; 16: 749-55)

Keywords: chemerin, diabetes, pulse wave velocity, atherosclerosis, carotid plaque, epicardial fat


Kadriye Aydın, Uğur Canpolat, Şafak Akın, Muhammet Dural, Jale Karakaya, Kudret Aytemir, Necla Özer, Alper Gürlek. Chemerin is not associated with subclinical atherosclerosis markers in prediabetes and diabetes. Anatol J Cardiol. 2016; 16(10): 749-755

Corresponding Author: Alper Gürlek, Türkiye


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright © 2018 Turkish Society of Cardiology