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Effects of Factor V Leiden on Prognosis in Patients With Acute Myocardial Infarction [Anatol J Cardiol]
Anatol J Cardiol. 2001; 1(4): 242-245

Effects of Factor V Leiden on Prognosis in Patients With Acute Myocardial Infarction

Merih Baykan1, Şükrü Çelik2, Fahri Uçar3, Şahin Kaplan4, Ercüment Ovalı3, Cevdet Erdöl2
1Karadeniz Teknik Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Trabzon, Türkiye
2Karadeniz Teknik Üniversitesi Tıp Fakültesi Kardiyoloji Bilim Dalı, Trabzon
3Karadeniz Teknik Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı, Trabzon
4Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey

Objective: Factor V Leiden mutation, the genetic defect underlying resistance to activated protein C, is the most common risk factor for venous thrombosis. Factor V Leiden mutation and its relation to post-myocardial infarction (MI) complications including angina pectoris, heart failure, reinfarction and cardiac mortality has not been investigated. We aimed to investigate this relation. Methods: The prevalence of factor V Leiden mutation was investigated in 122 patients with first acute myocardial infarction (aged 56±11, 82 men/40 women). These patients were divided into two groups according to whether the patients had factor V Leiden mutation (Group I) or not (Group II). Post MI complications were evaluated during 18 months. Blood samples from the patients were analyzed for factor V Leiden mutation by DNA analysis, using the polymerase chain reaction (PCR). Results: Factor V Leiden was detected in 11 (9%) patients (aged; 54±10, 5 women/ men) and was not detected in 111(90%) patients (aged; 56±11; 35 women/76 men) of the 122 patients. There were no significant differences between Group I and Group II in terms of post MI complications, including reinfarction (27% vs. 29%; p>0.05, respectively), angina pectoris (45% vs. 38%; p>0.05, respectively), heart failure (27% vs. 23%; p>0.05, respectively) and cardiac mortality (18% vs. 14%; p>0.05, respectively). Conclusion: Post MI complications, including reinfarction, heart failure, angina pectoris and cardiac mortality were not increased in patients with factor V Leiden.

Keywords: Faktör V Leiden, miyokard infarktüsü

Merih Baykan, Şükrü Çelik, Fahri Uçar, Şahin Kaplan, Ercüment Ovalı, Cevdet Erdöl. Effects of Factor V Leiden on Prognosis in Patients With Acute Myocardial Infarction. Anatol J Cardiol. 2001; 1(4): 242-245

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