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Association between parathyroid hormone levels and the extensiveness of coronary artery disease [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(11): 839-843 | DOI: 10.14744/AnatolJCardiol.2016.6799  

Association between parathyroid hormone levels and the extensiveness of coronary artery disease

Yakup Alsancak1, Emrullah Kızıltunç2, Burak Sezenöz4, Selçuk Özkan5, Aybüke Demir Alsancak3, Murat Gül6, Atiye Çengel7
1Department of Cardiology, Atatürk Education and Research Hospital, Ankara-Turkey
2Departments of Cardiology, Numune Education and Research Hospital, Ankara-Turkey
3Family Medicine, Numune Education and Research Hospital, Ankara-Turkey
4Department of Cardiology, Gazi Mustafa Kemal State Hospital, Ankara-Turkey
5Department of Cardiology, 29 Mayıs State Hospital, Ankara-Turkey
6Department of Cardiology, Erciş State Hospital, Van-Turkey
7Department of Cardiology, Faculty of Medicine, Gazi University, Ankara-Turkey

Objective: Previous studies have suggested that there is a relationship between coronary artery disease (CAD) and parathyroid hormone (PTH) levels. Here, we aimed to evaluate the association between PTH levels and severity of CAD.
Methods: Patients were divided into two groups based on their serum PTH values. Patients with PTH levels ≤72 pg/mL were accepted as Group 1 (n=568) and >72 pg/mL as Group 2 (n=87). Gensini score system and >50% stenosis in any coronary artery with conventional coronary angiog- raphy were used to determine the extensiveness of CAD. This study was designed as a prospective and cross-sectional study.
Results: Baseline characteristics except for age, gender, and blood pressure were similar between groups. Mean serum PTH levels of the entire cohort was 43.4±29.5 pg/mL. Median Gensini score was 19.5 in Group 1 and 14.5 in Group 2 (p=0.75). On the other hand, PTH levels were weakly correlated with Gensini score (Spearman’s Rho=0.11, p=0.003). Additionally, we did not observe a statistically significant difference between PTH levels and the number of stenotic vessels (p=0.14). This study was designed as a prospective and cross-sectional study.
Conclusion: There is no association between serum PTH levels and extensiveness of CAD. (Anatol J Cardiol 2016; 16: 839-43)

Keywords: atherosclerosis, coronary artery disease, parathyroid hormone, Gensini score


Yakup Alsancak, Emrullah Kızıltunç, Burak Sezenöz, Selçuk Özkan, Aybüke Demir Alsancak, Murat Gül, Atiye Çengel. Association between parathyroid hormone levels and the extensiveness of coronary artery disease. Anatol J Cardiol. 2016; 16(11): 839-843

Corresponding Author: Yakup Alsancak, Türkiye


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