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Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study [Anatol J Cardiol]
Anatol J Cardiol. 2013; 13(5): 465-470 | DOI: 10.5152/akd.2013.145  

Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study

Turan Erdoğan1, Sinan Altan Kocaman2, Mustafa Çetin2, Murtaza Emre Durakoğlugil3, Aynur Kırbaş4, Aytun Çanga2, Adnan Yılmaz5, Sıtkı Doğan2, Yüksel Çiçek6
1Department of Cardiology, Faculty of Medicine, Rize University, Rize-Turkey
2Clinic of Cardiology, Rize Education and Research Hospital, Rize-Turkey
3Department of Cardiology, Faculty of Medicine, Rize University, Rize-Turkey
4Departments of Biochemistry, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize-Turkey
5Departments of Cardiology and Biochemistry, Faculty of Medicine, Rize University, Rize-Turkey
6Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize-Turkey

Objective: YKL-40, a new biomarker of localized inflammation, is secreted by macrophages within the atherosclerotic plaques. Coronary artery ectasia (CAE) is a clinical entity with unclear etiopathogenesis. Some studies have revealed that CAE may be a form of atherosclerosis that has more localized and intense inflammatory properties than atherosclerosis. The goal of this study was to investigate YKL-40 and C-reactive protein (CRP) levels in patients with isolated CAE compared to patients with normal coronary arteries (NCA) and coronary artery disease (CAD). Methods: Our study has an observational and cross-sectional design. Forty-nine patients with isolated CAE (mean age: 60±10 years), 30 age-and gender-matched control participants with NCA (30 patients, mean age: 58±12 years) and 30 patients with CAD (mean age: 61±10 years), were included in the study. The relationship between YKL-40, CRP levels and the presence of CAE was investigated. Univariate and multiple logistic regression analysis were used for analysis of independent variables to predict CAE. Results: Serum YKL-40 levels were significantly different among study groups (NCA: 110±53 μg/L, CAE: 144±68 and CAD: 180±117, p=0.005). CAD group and CAE group had significantly higher YKL-40 levels than NCA group (p=0.004 and p=0.015, respectively). CRP was not significantly different between three groups. In addition, there were no any statistically significant differences, with respect to age, gender, the presence of hypertension or diabetes mellitus, and the smoking status (p>0.05). Logistic regression analysis revealed only YKL-40 level as the determinant of CAE (OR: 1.010, 95% CI: 1.001-1.019, p=0.027). Conclusion: YKL-40 levels in patients with isolated CAE compared to patients with NCA were found significantly high and only YKL-40 level was established as the determinant of CAE. We believe that further studies are needed to clarify the possible causative roles of YKL-40 in patients with isolated CAE.

Keywords: Coronary artery ectasia, YKL-40, C-reactive protein; coronary angiography, systemic inflammation, positive remodeling, regression analysis


Turan Erdoğan, Sinan Altan Kocaman, Mustafa Çetin, Murtaza Emre Durakoğlugil, Aynur Kırbaş, Aytun Çanga, Adnan Yılmaz, Sıtkı Doğan, Yüksel Çiçek. Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study. Anatol J Cardiol. 2013; 13(5): 465-470


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